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About Author contributions: Sara Massone and Eleonora Ciarlo, performed the most of the experiments. Ilaria Penna and Arianna Gigoni performed RT-PCR analysis. Mario Nizzari performed the fluorescence microscopy analysis. Claudio Russo performed the analysis of APP Cterminal fragments. Tullio Florio, Giogio Dieci and Ranieri Cancedda participated to the interpretation of results and critically read the manuscript. Aldo Pagano leaded the project, participated to the experiments and wrote the paper. © 2012. Published by The Company of Biologists Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.